NAD+

Product Overview

NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme found in every living cell. It plays a central role in cellular energy metabolism, serving as an essential electron carrier in the mitochondrial electron transport chain and as a substrate for key signaling enzymes including sirtuins (SIRT1-SIRT7) and poly-ADP-ribose polymerases (PARPs). NAD+ levels have been shown to decline with age in research models, driving significant scientific interest in NAD+ biology and supplementation research.

NXTSTATE provides NAD+ in high-purity form for laboratory and investigational research. Each batch is tested for purity and identity, with a Certificate of Analysis included.

Research Background

NAD+ has become one of the most actively studied molecules in aging and metabolic research. Published studies have examined its role in DNA repair (via PARP activation), gene expression regulation (via sirtuin activity), circadian rhythm maintenance, and mitochondrial function. The decline of cellular NAD+ with age has been linked in research models to metabolic dysfunction, neurodegeneration, and impaired cellular repair mechanisms.

Researchers have investigated multiple strategies for restoring NAD+ levels, including direct NAD+ supplementation and precursor-based approaches using NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside). Each approach has distinct pharmacokinetic properties and has been studied for its ability to elevate intracellular NAD+ in various tissue types.

Additional research has explored NAD+ in the context of immune function, inflammatory signaling (via CD38 activity), cardiac metabolism, hepatic function, and neuroprotection. The breadth of NAD+-dependent biological processes makes it a foundational molecule for understanding cellular health and aging at the molecular level.

Product Specifications

• Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
• Molecular Weight: ~663.43 g/mol
• Purity: ≥98% (verified)
• Form: Powder
• Quantity: 100mg
• Appearance: White to off-white powder
• Storage: Store at -20°C, protected from light and moisture

Quality Assurance

Every batch of NAD+ from NXTSTATE undergoes quality control testing including purity analysis, identity confirmation, and stability assessment. Our supply chain maintains strict storage and handling protocols to preserve compound integrity from manufacturing through delivery.

Handling and Storage

NAD+ should be stored at -20°C in a sealed container protected from light and moisture. When handling, use appropriate laboratory PPE and work in a clean environment. NAD+ is hygroscopic and sensitive to degradation in aqueous solution at elevated temperatures. Prepare working solutions fresh when possible and store dissolved NAD+ at 2-8°C for short-term use.

Compliance and Disclaimers

• For Research Use Only (RUO)
• Not for human consumption
• Not intended to diagnose, treat, cure, or prevent any disease
• Not approved for medical, cosmetic, food, or veterinary use
• The buyer assumes all responsibility for proper handling, storage, and use
• Must comply with all applicable local, state, and federal regulations

By purchasing this product, the buyer acknowledges it is being sold solely for research purposes and accepts all associated responsibility.