TB-500 (Thymosin Beta-4 fragment) is a naturally occurring peptide studied for its role in actin polymerization, cell migration, and tissue repair. Commonly co-studied with BPC-157 in musculoskeletal recovery models. 5mg lyophilized, ≥99% purity confirmed by third-party COA. Bacteriostatic Water required for reconstitution.
Every batch independently third-party lab tested. Pharma-grade lyophilization. Shipped from our US facility within 24–48 hours.
≥99% HPLC purity
Every batch verified by an independent third-party lab. COA available on request and in the product gallery.
Pharma-grade lyophilization
Stable, shelf-ready powder. Reconstitute with bacteriostatic water for research use.
Ships in 24–48 hours
From our US facility. Cold-chain packaging on every order. Tracking provided on dispatch.
COA per batch
Certificate of Analysis for every lot. Identity, purity, and quality data — included in the product gallery.
About this compound
More on TB-500.
TB-500 from NXTSTATE is a research-grade peptide tested at ≥99% HPLC purity. A third-party Certificate of Analysis is included on every lot. Below you will find specifications, research applications, and the standards every shipment meets.
Product Overview
TB-500 is a synthetic analog of Thymosin Beta-4, a naturally occurring 43-amino acid peptide found in virtually all human and animal cells. Thymosin Beta-4 plays a critical role in cellular processes including actin regulation, cell migration, and tissue repair signaling. TB-500 is the active fragment most commonly used in research settings due to its enhanced stability and targeted mechanism of action.
NXTSTATE supplies TB-500 in lyophilized form at research-grade purity, independently verified through HPLC analysis and mass spectrometry. Each vial includes a Certificate of Analysis documenting purity, identity, and quality metrics.
Research Background
TB-500 has been the subject of extensive preclinical investigation, with published studies examining its role in wound healing, tissue regeneration, and anti-inflammatory response modulation. Research models have explored its effects on dermal repair, cardiac tissue recovery, corneal healing, and musculoskeletal injury recovery.
A key mechanism of interest is TB-500s ability to upregulate actin, a cell-building protein essential for cell migration and proliferation. This upregulation has been studied in the context of new blood vessel formation (angiogenesis), stem cell maturation, and extracellular matrix remodeling. Researchers have also investigated its potential to modulate inflammatory cytokines such as IL-6, IL-1beta, and TNF-alpha.
TB-500 is frequently studied alongside BPC-157 in combination protocols, as the two peptides are thought to operate through complementary pathways. While BPC-157 is associated with nitric oxide and growth factor pathways, TB-500 research focuses more on actin polymerization and cell motility.
Product Specifications
Molecular Formula: C212H350N56O78S
Molecular Weight: ~4,963 g/mol
Purity: ≥99% (HPLC verified)
Form: Lyophilized powder
Quantity: 5mg per vial
Appearance: White to off-white powder
Storage: Store at -20°C for long-term, 2-8°C after reconstitution
Quality Assurance
NXTSTATE maintains strict quality control standards for all TB-500 inventory. Each production batch is tested for purity via HPLC, confirmed by mass spectrometry for molecular identity, and screened for endotoxins and microbial contamination. Certificates of Analysis are provided with every order, giving researchers full transparency into the quality of their materials.
Reconstitution and Handling
Reconstitute TB-500 with bacteriostatic water in a sterile laboratory environment. Inject the solvent slowly along the inside wall of the vial and gently swirl to dissolve. Do not shake vigorously. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles. The lyophilized powder should be stored at -20°C until ready for use.
Compliance and Disclaimers
For Research Use Only (RUO)
Not for human consumption
Not intended to diagnose, treat, cure, or prevent any disease
Not approved for medical, cosmetic, food, or veterinary use
The buyer assumes all responsibility for proper handling, storage, and use
Must comply with all applicable local, state, and federal regulations
By purchasing this product, the buyer acknowledges it is being sold solely for research purposes and accepts all associated responsibility.
Related Research on TB-500
Researchers often pair TB-500 with complementary compounds in the NXTSTATE catalog. Explore the full lab report library for third-party COAs on every lot, or browse the complete catalog for related research peptides. Independent peer-reviewed background is available through the PubMed research database.
Quality Standards Behind Every TB-500 Lot
Every lot leaving the NXTSTATE facility passes independent third-party HPLC testing. The Certificate of Analysis is matched to the batch number printed on each vial. Researchers can verify the COA before opening the package, then again at the bench. This level of transparency separates research-grade supply from grey-market sources.
Storage matters as much as sourcing. Each vial ships in lyophilized form with a desiccant pack and should be stored at -20°C until reconstituted. After reconstitution, refrigerate at 2-8°C. Following these conditions preserves potency throughout the research timeline. Cold-chain handling guidance ships with every order.
Related
Frequently asked
Common questions, answered.
Is this for human consumption?
No. All NXTSTATE products are sold strictly for laboratory research use only. They are not intended for human consumption, ingestion, or in vivo administration.
How is purity verified?
Every batch is independently tested by a third-party lab. The Certificate of Analysis confirms identity and ≥99% HPLC purity, and is included in the product gallery for every order.
How fast does it ship?
Orders placed before 2pm ET ship same-day. Most orders arrive in 24–48 hours within the US via expedited carrier. Tracking is sent on dispatch.
How should it be stored?
Lyophilized peptide should be stored sealed at room temperature, away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate and use within 30 days.
What payment methods do you accept?
Visa, Mastercard, Zelle, Cash App, and Venmo. Card processing handled securely via our processor. Off-platform options (Zelle/CashApp/Venmo) available at checkout.
