In lab testing, results expected mid October. Join the waitlist and you will be emailed the moment it is in stock.

5-Amino-1MQ from NXTSTATE is a research-grade NNMT inhibitor supplied as a 10mg vial. Every lot is sent for independent third-party HPLC testing, and the Certificate of Analysis is posted to our lab report library before a single vial ships. Below you will find specifications, research applications, and the standards every shipment meets.

Product Overview

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small, membrane permeable molecule rather than a peptide. It selectively inhibits nicotinamide N-methyltransferase, or NNMT, an enzyme that is highly expressed in fat tissue and liver. By blocking NNMT, 5-Amino-1MQ changes how cells handle nicotinamide and methyl groups, two inputs that sit at the center of cellular energy metabolism.

Because it works on an enzyme rather than a receptor, 5-Amino-1MQ gives researchers a very different angle on metabolism than the incretin peptides in the NXTSTATE catalog.

Research Background

NNMT uses S-adenosylmethionine to methylate nicotinamide, a precursor in the NAD+ salvage pathway. Elevated NNMT activity has been linked in published research to increased fat mass and reduced NAD+ availability in adipocytes. Inhibiting NNMT is therefore studied as a way to raise intracellular NAD+ and SAM levels and shift fat cells toward higher energy use.

Preclinical studies of 5-Amino-1MQ in diet induced obese mice reported reduced fat mass, smaller adipocytes and lower cholesterol without changes in food intake. Other work has looked at NNMT inhibition in muscle stem cells and aging muscle. 5-Amino-1MQ has not been approved for any medical use and is sold here strictly for research.

Product Specifications

• Compound: 5-amino-1-methylquinolinium
• Class: Small molecule NNMT inhibitor
• Molecular Formula: C₁₀H₁₁N₂⁺ (cation)
• Molecular Weight: ~159.2 g/mol (cation)
• Content: 10mg per vial
• Purity: Third-party HPLC report posted to the lab report library on release
• Form: Lyophilized powder
• Storage: Store at -20°C for long-term, 2-8°C after reconstitution

Quality Assurance

NXTSTATE does not release a new compound on a supplier’s word. This 5-Amino-1MQ lot is currently with an independent laboratory for HPLC purity testing and mass confirmation. When the report comes back it is matched to the batch number printed on each vial and published in full. Researchers on the waitlist are notified by email the moment the lot is cleared and in stock.

Reconstitution and Handling

Reconstitute 5-Amino-1MQ with bacteriostatic water in a clean laboratory environment, adding the diluent slowly down the side of the vial and swirling gently rather than shaking. Store at 2-8°C after reconstitution and use within 30 days. Keep the lyophilized powder at -20°C until ready for use and avoid repeated freeze-thaw cycles.

Compliance and Disclaimers

• For Research Use Only (RUO)
• Not for human consumption
• Not intended to diagnose, treat, cure, or prevent any disease
• Not approved for medical, cosmetic, food, or veterinary use
• The buyer assumes all responsibility for proper handling, storage, and use
• Must comply with all applicable local, state, and federal regulations

By purchasing this product, the buyer acknowledges it is being sold solely for research purposes and accepts all associated responsibility.

Related Research on 5-Amino-1MQ

Researchers often study 5-Amino-1MQ alongside NAD+ and MOTS-c in NAD+ and mitochondrial metabolism work, and alongside SS-31 in cellular energy models. Explore the full lab report library for third-party COAs on every lot, or browse the complete catalog for related research compounds. Independent peer-reviewed background on 5-Amino-1MQ is available through PubMed.

Quality Standards Behind Every 5-Amino-1MQ Lot

Every lot leaving the NXTSTATE facility passes independent third-party HPLC testing. The Certificate of Analysis is matched to the batch number printed on each vial, so researchers can verify the report before opening the package and again at the bench. This level of transparency separates research-grade supply from grey-market sources.

Storage matters as much as sourcing. Each vial ships in lyophilized form and should be stored at -20°C until reconstituted, then refrigerated at 2-8°C. Following these conditions preserves potency throughout the research timeline. Handling guidance ships with every order.