In lab testing, results expected mid October. Join the waitlist and you will be emailed the moment it is in stock.

IGF-1 LR3 from NXTSTATE is a research-grade analog of insulin-like growth factor 1 supplied as a 1mg lyophilized vial. Every lot is sent for independent third-party HPLC testing, and the Certificate of Analysis is posted to our lab report library before a single vial ships. Below you will find specifications, research applications, and the standards every shipment meets.

Product Overview

IGF-1 LR3, short for Long R3 IGF-1, is an 83 amino acid analog of human IGF-1. It differs from the native 70 amino acid hormone in two ways: arginine replaces glutamic acid at position 3, and a 13 amino acid extension is added to the N-terminus. Together these changes sharply reduce binding to IGF binding proteins, which normally hold most IGF-1 in an inactive state.

Because far less of it is sequestered by binding proteins, IGF-1 LR3 remains biologically available for longer than native IGF-1. That property made it a standard supplement in cell culture media and a common tool in growth factor research.

Research Background

IGF-1 is the main downstream mediator of growth hormone signaling. It acts through the IGF-1 receptor to activate the PI3K/Akt and MAPK pathways, which govern cell survival, proliferation, protein synthesis and glucose uptake. IGF-1 LR3 was developed specifically to study these effects without interference from binding proteins.

Researchers use IGF-1 LR3 in muscle cell (myoblast) proliferation and differentiation studies, in bioprocessing and cell culture work, and in metabolic models that examine IGF-1 receptor signaling alongside growth hormone secretagogues. IGF-1 LR3 is not approved for any medical use.

Product Specifications

• Compound: Long R3 IGF-1 (83 amino acids)
• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
• Molecular Weight: ~9,111 g/mol
• Content: 1mg per vial
• Purity: Third-party HPLC report posted to the lab report library on release
• Form: Lyophilized powder
• Appearance: White powder
• Storage: Store at -20°C for long-term, 2-8°C after reconstitution

Quality Assurance

NXTSTATE does not release a new compound on a supplier’s word. This IGF-1 LR3 lot is currently with an independent laboratory for HPLC purity testing and mass confirmation. When the report comes back it is matched to the batch number printed on each vial and published in full. Researchers on the waitlist are notified by email the moment the lot is cleared and in stock.

Reconstitution and Handling

Reconstitute IGF-1 LR3 with bacteriostatic water in a clean laboratory environment, adding the diluent slowly down the side of the vial and swirling gently rather than shaking. Store at 2-8°C after reconstitution and use within 30 days. Keep the lyophilized powder at -20°C until ready for use and avoid repeated freeze-thaw cycles. Larger proteins like IGF-1 LR3 are more sensitive to agitation than short peptides, so gentle handling matters.

Compliance and Disclaimers

• For Research Use Only (RUO)
• Not for human consumption
• Not intended to diagnose, treat, cure, or prevent any disease
• Not approved for medical, cosmetic, food, or veterinary use
• The buyer assumes all responsibility for proper handling, storage, and use
• Must comply with all applicable local, state, and federal regulations

By purchasing this product, the buyer acknowledges it is being sold solely for research purposes and accepts all associated responsibility.

Related Research on IGF-1 LR3

Researchers often study IGF-1 LR3 alongside growth hormone secretagogues such as CJC-1295, Ipamorelin and Tesamorelin to follow the growth hormone and IGF-1 axis end to end. Explore the full lab report library for third-party COAs on every lot, or browse the complete catalog for related research compounds. Independent peer-reviewed background on IGF-1 LR3 is available through PubMed.

Quality Standards Behind Every IGF-1 LR3 Lot

Every lot leaving the NXTSTATE facility passes independent third-party HPLC testing. The Certificate of Analysis is matched to the batch number printed on each vial, so researchers can verify the report before opening the package and again at the bench. This level of transparency separates research-grade supply from grey-market sources.

Storage matters as much as sourcing. Each vial ships in lyophilized form and should be stored at -20°C until reconstituted, then refrigerated at 2-8°C. Following these conditions preserves potency throughout the research timeline. Handling guidance ships with every order.