SS-31 from NXTSTATE is a research-grade mitochondrial peptide tested at ≥99% HPLC purity. A third-party Certificate of Analysis is included on every lot. Below you will find specifications, research applications, and the standards every shipment meets.

Product Overview

SS-31 (Elamipretide) is a synthetic tetrapeptide built from the sequence D-Arg-Dmt-Lys-Phe-NH2, one of the Szeto-Schiller family of mitochondria-targeted compounds. Its alternating aromatic and cationic residues allow it to cross cell membranes and concentrate in the inner mitochondrial membrane, where it associates with cardiolipin, the phospholipid that anchors the electron transport chain. SS-31 has been studied primarily in cellular energetics and oxidative stress research.

NXTSTATE provides SS-31 in lyophilized form at research-grade purity, verified by independent HPLC and mass spectrometry analysis. Each vial includes a Certificate of Analysis.

Research Background

The defining feature of SS-31 in the literature is its selective binding to cardiolipin. In published in vitro and preclinical work, this interaction has been reported to stabilize cristae structure, support cytochrome c function within the respiratory chain, and reduce the leakage of reactive oxygen species during electron transport. Because mitochondrial dysfunction sits upstream of many cellular aging models, SS-31 has become a reference compound in studies of bioenergetics, ATP production efficiency, and mitochondrial membrane potential.

Research groups have examined SS-31 across cardiac, skeletal muscle, renal, and neural cell models, frequently pairing it with mitochondrial-derived peptides such as MOTS-c and NAD+ precursors in comparative panels. Its small size, water solubility, and stability in solution have made SS-31 a practical tool for researchers investigating how membrane-level protection of mitochondria translates into cellular resilience under metabolic stress.

Product Specifications

• Molecular Formula: C₃₂H₄₉N₉O₅
• Molecular Weight: ~639.8 g/mol
• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Appearance: White powder
• Storage: Store at -20°C for long-term, 2-8°C after reconstitution

Quality Assurance

NXTSTATE maintains strict quality control for all SS-31 inventory. Each batch is tested for purity via HPLC, confirmed by mass spectrometry, and screened for contaminants. Certificates of Analysis are included with every order, and each lot number can be cross-checked against the report in our lab library before the vial is opened.

Reconstitution and Handling

Reconstitute SS-31 with sterile water or bacteriostatic water in a clean laboratory environment. Store at 2-8°C after reconstitution and use within 30 days. Keep the lyophilized powder at -20°C until ready for use. Avoid repeated freeze-thaw cycles.

Compliance and Disclaimers

• For Research Use Only (RUO)
• Not for human consumption
• Not intended to diagnose, treat, cure, or prevent any disease
• Not approved for medical, cosmetic, food, or veterinary use
• The buyer assumes all responsibility for proper handling, storage, and use
• Must comply with all applicable local, state, and federal regulations

By purchasing this product, the buyer acknowledges it is being sold solely for research purposes and accepts all associated responsibility.

Related Research on SS-31

Researchers often pair SS-31 with complementary compounds in the NXTSTATE catalog, most notably MOTS-c and NAD+ in mitochondrial biology work. Explore the full lab report library for third-party COAs on every lot, or browse the complete catalog for related research peptides. Independent peer-reviewed background is available through the PubMed research database.

Quality Standards Behind Every SS-31 Lot

Every lot leaving the NXTSTATE facility passes independent third-party HPLC testing. The Certificate of Analysis is matched to the batch number printed on each vial. Researchers can verify the COA before opening the package, then again at the bench. This level of transparency separates research-grade supply from grey-market sources.

Storage matters as much as sourcing. Each vial ships in lyophilized form with a desiccant pack and should be stored at -20°C until reconstituted. After reconstitution, refrigerate at 2-8°C. Following these conditions preserves potency throughout the research timeline. Cold-chain handling guidance ships with every order.