In lab testing, results expected mid October. Join the waitlist and you will be emailed the moment it is in stock.

Cagrilintide from NXTSTATE is a research-grade long-acting amylin analog supplied as a 5mg lyophilized vial. Every lot is sent for independent third-party HPLC testing, and the Certificate of Analysis is posted to our lab report library before a single vial ships. Below you will find specifications, research applications, and the standards every shipment meets.

Product Overview

Cagrilintide is a synthetic, long-acting analog of amylin, a 37 amino acid peptide hormone co-secreted with insulin by pancreatic beta cells. Native amylin has a very short half-life, which limits its usefulness in extended research models. Cagrilintide was engineered with amino acid substitutions and a fatty acid side chain that promotes albumin binding, extending its activity window and making it suitable for once-weekly dosing protocols in published studies. It acts as a nonselective agonist at amylin receptors and the calcitonin receptor.

In the research literature Cagrilintide is best known for its role in combination studies with GLP-1 receptor agonists, where amylin and incretin pathways are examined side by side. That makes Cagrilintide a natural companion to the incretin compounds already in the NXTSTATE metabolic catalog.

Research Background

Amylin signaling has been studied for decades for its effects on gastric emptying, postprandial glucagon, and satiety signaling in the area postrema and hypothalamus. Early amylin analogs required multiple daily administrations, which pushed researchers toward longer acting designs. Cagrilintide emerged from that work as a stable, acylated analog.

A published phase 2 dose-finding study of Cagrilintide appeared in The Lancet in 2021, and later trials examined Cagrilintide co-administered with semaglutide in a combination commonly referred to in the literature as CagriSema. Researchers use Cagrilintide to study amylin receptor pharmacology, energy balance, food intake regulation, and the interaction between amylin and GLP-1 pathways in metabolic models. Cagrilintide is not approved for any medical use, and all published findings refer to controlled clinical research settings.

Product Specifications

• Compound: Cagrilintide (long-acting acylated amylin analog)
• Molecular Formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂
• Molecular Weight: ~4409 g/mol
• Content: 5mg per vial
• Purity: Third-party HPLC report posted to the lab report library on release
• Form: Lyophilized powder
• Appearance: White powder
• Storage: Store at -20°C for long-term, 2-8°C after reconstitution

Quality Assurance

NXTSTATE does not release a new compound on a supplier’s word. This Cagrilintide lot is currently with an independent laboratory for HPLC purity testing and mass confirmation. When the report comes back it is matched to the batch number printed on each vial and published in full. Researchers on the waitlist are notified by email the moment the lot is cleared and in stock.

Reconstitution and Handling

Reconstitute Cagrilintide with bacteriostatic water in a clean laboratory environment, adding the diluent slowly down the side of the vial and swirling gently rather than shaking. Store at 2-8°C after reconstitution and use within 30 days. Keep the lyophilized powder at -20°C until ready for use and avoid repeated freeze-thaw cycles, which can degrade longer peptides.

Compliance and Disclaimers

• For Research Use Only (RUO)
• Not for human consumption
• Not intended to diagnose, treat, cure, or prevent any disease
• Not approved for medical, cosmetic, food, or veterinary use
• The buyer assumes all responsibility for proper handling, storage, and use
• Must comply with all applicable local, state, and federal regulations

By purchasing this product, the buyer acknowledges it is being sold solely for research purposes and accepts all associated responsibility.

Related Research on Cagrilintide

Researchers often study Cagrilintide alongside incretin compounds such as GLP-3RT and GLP-2TZ, and alongside mitochondrial peptides like MOTS-c in broader metabolic work. Explore the full lab report library for third-party COAs on every lot, or browse the complete catalog for related research peptides. Independent peer-reviewed background on Cagrilintide is available through PubMed.

Quality Standards Behind Every Cagrilintide Lot

Every lot leaving the NXTSTATE facility passes independent third-party HPLC testing. The Certificate of Analysis is matched to the batch number printed on each vial, so researchers can verify the report before opening the package and again at the bench. This level of transparency separates research-grade supply from grey-market sources.

Storage matters as much as sourcing. Each vial ships in lyophilized form and should be stored at -20°C until reconstituted, then refrigerated at 2-8°C. Following these conditions preserves potency throughout the research timeline. Handling guidance ships with every order.